1. Kukonzekera kwa nthunzi yoyera mu zomera za biopharmaceutical
Kuchokera kumagulu ogwira ntchito, dongosolo la nthunzi loyera lili ndi magawo awiri: gawo lokonzekera ndi gawo logawa.Majenereta oyera a nthunzi nthawi zambiri amagwiritsa ntchito nthunzi ya mafakitale ngati gwero la kutentha, ndipo amagwiritsa ntchito zotenthetsera ndi mizati ya nthunzi kusinthanitsa kutentha ndi kupanga nthunzi, potero amalekanitsa bwino nthunzi-zamadzimadzi kuti apeze nthunzi yoyera.Pakalipano, njira ziwiri zodziwika bwino zokonzekera nthunzi zimaphatikizapo kuwira kwa nthunzi ndi kugwa kwa filimu.
Jenereta ya nthunzi yowira yowira ndiyo njira yachikhalidwe yosinthira madzi.Madzi osaphika amatenthedwa ndikusinthidwa kukhala nthunzi yosakanikirana ndi madontho ang'onoang'ono.Madontho ang'onoang'ono amasiyanitsidwa ndi mphamvu yokoka ndipo amatulukanso nthunzi.Nthunziyo imalowa m'gawo lolekanitsa kudzera pa chipangizo chopangidwa mwapadera cha waya woyeretsa kenako ndikulowa munjira yogawa kudzera papaipi yotulutsa.Mfundo zosiyanasiyana ntchito.
Majenereta a nthunzi omwe akugwa nthawi zambiri amagwiritsa ntchito gawo lomwelo la evaporation ngati gawo loyamba la makina otulutsa madzi ambiri.Mfundo yaikulu ndi yakuti madzi aiwisi omwe amatenthedwa amalowa pamwamba pa evaporator kudzera pa mpope wozungulira ndipo amagawidwa mofanana mumzere wa evaporation kudzera mu chipangizo chogawa mbale.Kuthamanga kwamadzi ngati filimu kumapangidwa mu chubu, ndipo kutentha kwa kutentha kumayendetsedwa kudzera mu nthunzi ya mafakitale;filimu yamadzimadzi mu chubu imasunthidwa mwachangu kukhala nthunzi, ndipo nthunziyo imapitilirabe mu evaporator, ndikudutsa mu chipangizo cholekanitsa cha nthunzi, ndipo imakhala nthunzi yoyera kuchokera ku koyera. pyrogen imatulutsidwa mosalekeza pansi pa ndime.Nthunzi yaying'ono yoyera imatsitsidwa ndikusonkhanitsidwa ndi sampuli ya condensation, ndipo ma conductivity amayesedwa pa intaneti kuti adziwe ngati nthunzi yoyera ili yoyenera.
2. Kugawidwa kwa nthunzi yoyera mu zomera za biopharmaceutical
Gawo logawa makamaka limaphatikizapo maukonde ogawa mapaipi ndi mfundo zogwiritsira ntchito.Ntchito yake yayikulu ndikunyamula nthunzi yoyera kupita kumalo omwe amafunikira pamlingo wina wothamanga kuti akwaniritse kuthamanga kwake, kupanikizika ndi kutentha, komanso kusunga mpweya wabwino wa nthunzi motsatira zofunikira za pharmacopoeia ndi GMP.
Zigawo zonse muzitsulo zoyera zogawira nthunzi ziyenera kukhala zowonongeka, mapaipi ayenera kukhala ndi malo otsetsereka oyenerera, valavu yodzipatula yosavuta yodzipatula iyenera kuikidwa pamalo ogwiritsira ntchito ndipo msampha wa nthunzi wotsogoleredwa uyenera kuikidwa kumapeto.Popeza kutentha kwa ntchito ya nthunzi yoyera ndi yokwera kwambiri, kwa mafakitale a biopharmaceutical, makina opangidwa bwino a mapaipi a nthunzi omwe ali ndi ntchito yodziletsa okha, ndipo chiopsezo cha kuipitsidwa kwa tizilombo toyambitsa matenda ndi chochepa.
Njira zogawira nthunzi zoyera zimayenera kutsata njira zaumisiri zomwezo ndipo nthawi zambiri zimagwiritsa ntchito giredi 304, 316, kapena 316L yosapanga dzimbiri zosapanga dzimbiri, kapena chitoliro chokoka bwino.Popeza kuyeretsa nthunzi ndikodziletsa, kupukuta pamwamba si chinthu chofunikira kwambiri ndipo mapaipi amayenera kupangidwa kuti alole kukula kwamafuta ndi kukhetsa kwa condensate.